CHINESE MEDICINE

ROYAL MONACO RIVIERA WEB MAGAZINE

CHINESE MEDICINE

Luigi Mattera is a certified by CERFPA (St. Laurent du Var-France) HOMEOPATHY & ZUO TUINA MASSAGE OF TRADITIONAL CHINESE MEDICINE

Presents:

Editor-in-Chief

• Hin Wing Yeung, International Society for Chinese Medicine

Editorial Board

Society Affiliations

Chinese Medicine is the official journal of the International Society for Chinese Medicine.

Research

Neuroprotective and anti-oxidant effects of caffeic acid isolated from Erigeron annuus leaf

Chang-Ho Jeong, Hee Rok Jeong, Gwi Nam Choi, Dae-Ok Kim, Uk Lee and Ho Jin Heo

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Chinese Medicine 2011, 6:25 doi:10.1186/1749-8546-6-25

Published: 24 June 2011

Abstract (provisional)

Background

Since oxidative stress has been implicated in a neurodegenerative disease such as Alzheimer's disease (AD), natural antioxidants are promising candidates of chemopreventive agents. This study examines antioxidant and neuronal cell protective effects of various fractions of the methanolic extract of Erigeron annuus leaf and identifies active compounds of the extract.

Methods

Antioxidant activities of the fractions from Erigeron annuus leaf were examined with [2,2-azino-bis(3-ethylbenz thiazoline-6-sulfonic acid diammonium salt)] (ABTS ) and ferric reducing antioxidant power (FRAP) assays. Neuroprotective effect of caffeic acid under oxidative stress induced by H2O2 was investigated with [3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide] (MTT) and lactate dehydrogenase (LDH) assays.

Results

This study demonstrated that butanol fraction had the highest antioxidant activity among all solvent fractions from methanolic extract Erigeron annuus leaf. Butanol fraction had the highest total phenolic contents (396.49mg of GAE/g). Caffeic acid, an isolated active compound from butanol fraction, showed dose-dependent in vitro antioxidant activity. Moreover, neuronal cell protection against oxidative stress induced cytotoxicity was also demonstrated.

Conclusion

Erigeron annuus leaf extracts containing caffeic acid as an active compound have antioxidative and neuroprotective effects on neuronal cells.

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